Maybe just throw away your pachymeter...
Contrary to our usual thinking, today the British Journal of Ophthalmology (BJO) released a powerful Mendelian randomization study revealing a positive correlation between central corneal thickness (CCT) and primary open-angle glaucoma (POAG). The research, utilizing genome-wide association studies and summary statistics from FinnGen and UK Biobank databases, reveals a positive causal effect of CCT on POAG risk.
Interestingly, this effect is not mediated through intraocular pressure (IOP) changes. The study's findings challenge previous CCT observational assumptions supporting a CCT-POAG inverse relationship, with thin CCT thought to be an independent risk factor for POAG.
These results have significant clinical implications for us, potentially influencing glaucoma screening, risk assessment, and especially treatment decisions. While the exact mechanism remains unclear, this study's robust methodology provides compelling evidence for reconsidering CCT's role in glaucoma risk and management.
-JRM
Go to the article in BJO:
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55:54 (Audio Only) FREE ACCESS
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