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There has been promising results utilizing photobiomodulation as a potential treatment for retinitis pigmentosa (RP), as well as other retinal conditions such as macular degeneration (AMD), Stargardt's, and diabetic retinopathy. Recent findings utilizing multiwavelength photobiomodulation in RP, specifically the LumiThera Valeda Light Delivery System, showed improvement in visual function.
The treatment, which employs yellow (590 nm), red (660 nm), and near-infrared (850 nm) light wavelengths, was administered over nine sessions. Light wavelengths between 630 and 1000 nm are hypothesized to interact with the cellular mitochondrial enzyme cytochrome c oxidase, initiating signaling mechanisms which optimize mitochondrial energy metabolism, promote antioxidant production, thereby enhancing cellular function and survival.
Individuals showed a statistically significant improvement in best-corrected visual acuity from 0.62 to 0.53 logMAR. While visual field changes were not statistically significant, there was a trend towards improvement. Importantly, no adverse effects or abnormalities were observed via optical coherence tomography or electroretinogram results during the follow-up period.
The results suggest photobiomodulation may offer a safe and potentially effective approach for managing RP, warranting additional investigations with larger patient cohorts and extended follow-up periods.
-JRM
Go to the article in Clinical Ophthalmology:
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