Why do bisphosphonates increase risk?...
There appears to be a significant association between bisphosphonate use and the risk of angle closure glaucoma in patients with osteoporosis.
A retrospective cohort study reviewing over 200,000 patients found individuals being treated with bisphosphonates were 1.78 times more likely to develop acute angle closure (AAC) compared to non-users. And risedronate showed an even higher risk, with an adjusted incidence rate ratio of 2.12. However, no increased risk for open-angle glaucoma was found with bisphosphonate use.
These results highlight the importance of our increased awareness regarding elevated risk and the possibility of AAC with our osteoporosis patients being managed with bisphosphonates.
- JRM
Go to the article in Nature: Eye
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